Central obesity is detrimental to anti-inflammatory, phenotype, and exhaustion markers in mononuclear cells - A cross-sectional study.

OBJECTIVE: To investigate the role of central obesity on immunometabolic response in peripheral blood mononuclear cells (PBMCs) from normal weight and overweight/obese young men. METHODS: Eighteen individuals were classified as normal weight (NW; n = 9 - age: 25 ± 5 and BMI: 21.4 ± 1.7) and overweight/obese (OW; n = 9 - age: 29 ± 7 and BMI: 29.2 ± 2.7). The body composition was evaluated by dual-energy x-ray absorptiometry (DXA), waist circumference, and visceral and subcutaneous fat depots by ultrasound. Physical activity levels, metabolic parameters, immune phenotypic characterization, cytokine production by lipopolysaccharide (LPS) -stimulated whole blood cells and LPS or phorbol 12-myristate 13-acetate (PMA)-stimulated PBMC, and mitochondrial respiration in PBMCs were evaluated. Expression of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPAR-γ), nuclear factor-kappa B (NF-κB), toll-like receptor 4 (TLR-4), hypoxia-inducible factor-1 alpha (HIF-1α), and adrenergic receptor beta 1 and 2 (AR-ß1 and ß2) genes were evaluated in cultured PBMC using quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: Individuals with overweight/obese (OW) presented higher glucose (P = 0.009) and leptin (P = 0.010) than individuals with normal weight (NW). PBMCs of OW under stimulation with LPS presented a lower production of interleukin-10 (IL-10) (P = 0.011) and macrophage inflammatory protein-1alpha (MIP-1α) (P = 0.048) than NW. Mitochondrial respiration rates were not different between NW and OW subjects. Cultured PBMCs in LPS-stimulated condition indicated higher gene expression of AR-ß2 in OW, while PMA-stimulated PBMCs presented lower expression of AMPK (P = 0.002) and higher expression of NF-κB (P=<0.0001) than NW. OW presented higher numbers of CD3+CD4+ T cells (P = 0.009) and higher expression of programmed cell death protein 1 (PD-1) in CD8+ T cells (P = 0.001) than NW. CONCLUSION: Central obesity promoted reductions in interleukin 10 production response and increase in AR-ß2 expressions in mitogen-stimulated PBMCs. Furthermore, central obesity altered the phenotype of PBMCs, also increasing the expression of PD-1 exhaustion markers in young adults.

Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level- an observational sub-analysis fit- COVID study.

Aim: This study aimed to evaluate if physical activity is associated with systemic and cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. Methods: Mild- to- moderate post-COVID-19 patients (70.50 ± 43.10 days of diagnosis; age: 29.4 (21.9- 34.9) years; BMI: 25.5 ± 4.3 kg m2 n = 20) and healthy age-matched controls (age: 29.3 (21.2 - 32.6) years; BMI: 25.4 ± 4.7 kg m2; n = 20) were evaluated. Physical activity levels (PAL), body composition, dietary habits, muscular and pulmonary function, mental health, sleep quality, metabolic parameters, immune phenotypic characterization, stimulated whole blood and PBMC culture (cytokine production), mRNA, and mitochondrial respiration in PBMCs were evaluated. Results: The post-COVID-19 group exhibited lower levels of moderate to vigorous physical activity (MVPA) (p = 0.038); therefore, all study comparisons were performed with adjustment for MVPA. Post-COVID-19 impacted the pulmonary function (FEV1, FEV1%pred, FVC, and FVC %pred) compared with the control (p adjusted by MVPA (p adj) <0.05). Post-COVID-19 exhibited lower levels of serum IL-6 (p adj <0.01), whereas it showed higher serum IL-10, triglyceride, leptin, IgG, ACE activity, TNFRSF1A, and PGE2 (p adj <0.05) levels compared with controls. Post-COVID-19 presented a lower percentage of Treg cells (p adj = 0.03) and altered markers of lymphocyte activation and exhaustion (lower CD28 expression in CD8+ T cells (p adj = 0.014), whereas CD4+T cells showed higher PD1 expression (p adj = 0.037)) compared with the control group. Finally, post- COVID-19 presented an increased LPS-stimulated whole- blood IL-10 concentration (p adj <0.01). When exploring mitochondrial respiration and gene expression in PBMCs, we observed a higher LEAK state value (p adj <0.01), lower OXPHOS activity (complex I) (p adj = 0.04), and expression of the Rev-Erb-α clock mRNA after LPS stimulation in the post-COVID-19 patients than in the control (p adj <0.01). Mainly, PAL was associated with changes in IL-10, triglyceride, and leptin levels in the plasma of post-COVID-19 patients. PAL was also associated with modulation of the peripheral frequency of Treg cells and the expression of PD-1 in CD8+ T cells, although it abrogated the statistical effect in the analysis of TNF-α and IL-6 production by LPS- and PMA-stimulated PBMC of post-COVID-19 patients. Conclusion: Young adults after mild-to-moderate SARS-CoV-2 infection appeared to have lower physical activity levels, which can be associated with clinical and immunometabolic responses in a complex manner.

Older adults physically inactive in occupational and commuting domains have a higher risk for osteopenia and osteoporosis: A 12-month prospective study.

The relationship between different domains of physical activity (PA) and bone health in older adults needs to be further investigated. We evaluated 379 Brazilian older adults and observed that the risk of osteopenia is higher in older adults who are physically inactive in occupational domain and for osteoporosis the risk is higher in physically inactive in commuting domain and total habitual PA. PURPOSE: Bone mineral density (BMD) usually decreases with age, and the risk of osteometabolic diseases, such as osteopenia and osteoporosis, increases in older adults. PA is strictly related to BMD. However, the relationship between different domains of PA and bone health in older adults is still unclear, and needs to be further investigated, aiming at the implementation of preventative health measures for this population. Thus, the aim of the current study was to analyze the association between different domains of PA and the risk for osteopenia and osteoporosis in older adults in a 12-month follow-up. METHODS: Prospective study that included 379 Brazilian community-dwelling older adults, aged ≥ 60 years (70 ± 7 years, 69% women). Areal bone mineral density (aBMD) total, proximal femur, and lumbar spine were measured by dual energy X-ray absorptiometry (DXA), and PA was self-reported. Binary logistic regression analysis and 95%CI were used to analyze the association between the practice of PA in different domains (at baseline and follow-up) and risk for osteopenia and osteoporosis (follow-up). RESULTS: The risk for osteopenia (total proximal femur or lumbar spine) is higher in older adults who are physically inactive in the occupational domain (OR:3.25; 95%CI:1.24-8.55). In addition, older adults who are physically inactive in the commuting domain (OR:3.43; 95%CI:1.09-10.82) and total PA (OR:5.58; 95%CI:1.57-19.88) present a higher risk for osteoporosis (total proximal femur or lumbar spine) compared to physically active older adults. CONCLUSION: The risk of osteopenia is higher in older adults who are physically inactive in occupational domain and for osteoporosis the risk is higher in physically inactive in commuting domain and total habitual PA.

Autonomic Function Recovery and Physical Activity Levels in Post-COVID-19 Young Adults after Immunization: An Observational Follow-Up Case-Control Study.

Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but the literature on long-term recovery of young adults after mild to moderate infection is lacking. Heart rate variability (HRV) allows for the observation of autonomic nervous system (ANS) modulation post-SARS-CoV-2 infection. Since physical activity (PA) can help improve ANS modulation, investigating factors that can influence HRV outcomes after COVID-19 is essential to advancements in care and intervention strategies. Clinicians may use this research to aid in the development of non-medication interventions. At baseline, 18 control (CT) and 20 post-COVID-19 (PCOV) participants were observed where general anamnesis was performed, followed by HRV and PA assessment. Thus, 10 CT and 7 PCOV subjects returned for follow-up (FU) evaluation 6 weeks after complete immunization (two doses) and assessments were repeated. Over the follow-up period, a decrease in sympathetic (SNS) activity (mean heart rate: p = 0.0024, CI = -24.67--3.26; SNS index: p = 0.0068, CI = -2.50--0.32) and increase in parasympathetic (PNS) activity (mean RR: p = 0.0097, CI = 33.72-225.51; PNS index: p = 0.0091, CI = -0.20-1.47) were observed. At follow-up, HRV was not different between groups (p > 0.05). Additionally, no differences were observed in PA between moments and groups. This study provides evidence of ANS recovery after SARS-CoV-2 insult in young adults over a follow-up period, independent of changes in PA.

Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections-A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study.

Background: This proposal aims to explain some of the gaps in scientific knowledge on the natural history of coronavirus disease (COVID-19), with a specific focus on immune, inflammatory, and metabolic markers, in parallel with temporal assessment of clinical and mental health in patients with COVID-19. The study will explore the temporal modulatory effects of physical activity and body composition on individual trajectories. This approach will provide a better understanding of the survival mechanisms provided by the immunomodulatory role of physical fitness. Methods: We will conduct a prospective observational cohort study including adult patients previously infected with the SARS-CoV-2 virus who have expressed a mild to moderate COVID-19 infection. Procedures will be conducted for all participants at baseline, six weeks after vaccination, and again at 12 months. At each visit, a venous blood sample will be collected for immune phenotypic characterization and biochemistry assays (inflammatory and metabolic parameters). Also, body composition, physical activity level, cardiovascular and pulmonary function, peripheral and respiratory muscle strength, functional exercise capacity, and mental health will be evaluated. Using the baseline information, participants will be grouped based on physical activity levels (sedentary versus active), body composition (normal weight versus overweight or obese), and SARS-CoV-2 status (positive versus negative). A sub-study will provide mechanistic evidence using an in-vitro assay based on well-trained individuals and age-matched sedentary controls who are negative for SARS-CoV-2 infection. Whole blood will be stimulated using recombinant human coronavirus to determine the cytokine profile. Peripheral blood mononuclear cells (PBMCs) from healthy well-trained participants will be collected and treated with homologous serum (from the main study; samples collected before and after the vaccine) and recombinant coronavirus (inactive virus). The metabolism of PBMCs will be analyzed using Respirometry (Seahorse). Data will be analyzed using multilevel repeated-measures ANOVA. Conclusions: The data generated will help us answer three main questions: (1) Does the innate immune system of physically active individuals respond better to viral infections compared with that of sedentary people? (2) which functional and metabolic mechanisms explain the differences in responses in participants with different physical fitness levels? and (3) do these mechanisms have long-term positive modulatory effects on mental and cardiovascular health? Trial registration number: Brazilian Registry of Clinical Trials: RBR-5dqvkv3. Registered on 21 September 2021.

Resistance but not elastic tubes training improves bioimpedance vector patterns and body composition in older women: A randomized trial.

The present study aimed to investigate the effects of traditional resistance training compared to elastic tubes training on bioimpedance vector patterns, body composition, and strength in older women. Thirty-eight older women (age 68.7 ±â€¯6.9 years, body mass index 28.8 ±â€¯7.2 kg/m2) were randomly assigned to perform traditional resistance or elastic tubes training three times per week for 12 weeks. Body composition was assessed by dual energy X-ray absorptiometry and bioelectrical impedance vector analysis. In addition, handgrip strength was measured using a dynamometer. Only the participants who followed the 12-week traditional resistance training program significantly (p < 0.05) decreased fat mass (ES: -0.69) and extracellular water (ES: -1.06), and increased total body water (ES: 0.49), intracellular water (ES: 1.11), body cell mass (ES: 0.82), muscle mass (ES: 0.94), and phase angle (ES: 0.99), while no change occurred in the elastic tubes training group. Furthermore, a vector leftward displacement (ES: 1.11) into the resistance-reactance graph was found only after the traditional resistance training program. The handgrip strength increased for both traditional and elastic tubes training groups (ES: 0.64, ES: 0.71, respectively). Traditional resistance training improved body composition and strength in the older women group, while training using elastic tubes was effective only for the latter. The present outcomes encourage the use of systematic resistance training to counteract the effects of aging in older women.

Predictive equation for assessing appendicular lean soft tissue mass using bioelectric impedance analysis in older adults: Effect of body fat distribution.

BACKGROUND: Low muscle mass is associated with sarcopenia and increased mortality. Muscle mass, especially that of the limbs, is commonly estimated by dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA). However, BIA-based predictive equations for estimating lean appendicular soft tissue mass (ALST) do not take into account body fat distribution, an important factor influencing DXA and BIA measurements. OBJECTIVES: To develop and cross-validate a BIA-based equation for estimating ALST with DXA as criterion, and to compare our new formula to three previously published models. METHODS: One-hundred eighty-four older adults (140 women and 44 men) (age 71.5 ±â€¯7.3 years, body mass index 27.9 ±â€¯5.3 kg/m2) were recruited. Participants were randomly split into validation (n = 118) and cross-validation groups (n = 66). Bioelectrical resistance was obtained with a phase-sensitive 50 kHz BIA device. RESULTS: A BIA-based model was developed for appendicular lean soft tissue mass [ALST (kg) = 5.982 + (0.188 × S2 / resistance) + (0.014 × waist circumference) + (0.046 × Wt) + (3.881 × sex) - (0.053 × age), where sex is 0 if female or 1 if male, Wt is weight (kg), and S is stature (cm) (R2 = 0.86, SEE = 1.35 kg)]. Cross validation revealed r2 of 0.91 and no mean bias. Two of three previously published models showed a trend to significantly overestimate ALST in our sample (p < 0.01). CONCLUSIONS: The new equation can be considered valid, with no observed bias and trend, thus affording practical means to quantify ALST mass in older adults.

Are bioelectrical parameters and functionality associated with postural control in the elderly?

BACKGROUND: Alterations in bioimpedance parameters and postural control occur with aging and contribute to the increased risk of falls. The aim of this study was to evaluate the balance behavior in relation to bioimpedance and functionality. METHODS: We evaluated 21 elderly (men: 77.3 ± 9.5 years; women: 74.2 ± 9.6 years). The balance in standing posture was measured by the movement of the pressure center in seven positions. Bioimpedance was defined by its parameters resistance, reactance and phase angle, and functionality through the Timed Up and Go Test and Short Physical Performance Battery. FINDINGS: In the analysis of the mediolateral velocity at the positions feet separated with open and closed eyes, feet together with eyes closed and semi-tandem with eyes open on the platform, an inverse correlation between balance and bioimpedance variables were verified for all models, with a coefficient of determination varying between 20% and 74%. Inverse and significant correlations between reactance and phase angle in the one-legged-support position were verified, in all adjustment models, with coefficient of determination varying between 62% and 91%. In the analysis of mediolateral velocity for the semi-tandem eyes closed position, positive correlation with TUG and an inverse correlation with bioimpedance parameters and pennation angle were observed, with coefficient of determination varying between 21% and 67%. INTERPRETATION: The postural control is linearly related to bioimpedance parameters and functionality in the elderly. The assessment of balance can provide important information and furnishes useful insights for prevention and treatment strategies in elderly.

Occupational and leisure-time physical activity decreases the odds of disability in older adults: Prospective study.

AbstractAging decreases physical function which can increase dependence in activities of daily living (ADL) and disability. However, physical activity (PA) may improve physical function and prevent disability in older adults. In addition, it is important to emphasize that research concerning the domains in which PA is practiced and the benefits for physical function of older adults is also important for the elaboration of preventative health measures for this population. Thus, the aim of this study was to analyse the association of total PA and PA in different domains and odds of disability in older adults in a 24-month follow-up. The study included 211 older adults, aged ≥60 years (72 ± 7 years, 72% women). Handgrip strength was measured using a digital dynamometer, gait speed and chair stand by functional tests. PA and dependence in ADL were self-reported. Older adults who remained sufficiently active in the occupational (OR:0.11;CI95%:0.01-0.93, OR:0.21;CI95%:0.07-0.69, and OR:0.13;CI95%:0.05-0.34) domain presented protection for high dependence in basic (BADL), instrumental (IADL) and advanced (AADL), respectively, as well as in total ADL (OR:0.25;CI95%:0.07-0.92). Older adults who remained sufficiently active in the leisure-time exercise (OR:0.28;CI95%:0.11-0.72, OR:0.44;CI95%:0.20-0.93 and OR:0.15;CI95%:0.04-0.49) domain presented protection for high dependence in IADL, AADL and total ADL, respectively. Moreover, older adults who remained sufficiently active in total PA (OR:0.11;CI95%:0.01-0.94, OR:0.30;CI95%:0.11-0.80 and OR:0.21CI95%:0.10-0.46) presented protection for high dependence in BADL, IADL and AADL, respectively, as well as in total ADL (OR:0.28;CI95%:0.09-0.86). The odds of disability are lower in older adults who are sufficiently active, especially in occupational and leisure-time exercise domains.

Sedentary Patterns Are Associated with Bone Mineral Density and Physical Function in Older Adults: Cross-Sectional and Prospective Data.

Aging causes some unfavorable morphological and functional changes, such as the decline in bone mineral density (BMD) and physical function. Moderate-to-vigorous physical activity (MVPA) and sedentary time seem to be related with these alterations, but the impact of distinct patterns remains unclear. The aim of this study was to cross-sectionally and prospectively assess the association between objectively measured MVPA and sedentary patterns (bouts and breaks) with BMD and physical function in older adults. The study considered 151 Brazilians (aged ≥ 60 years), out of which 68 participants completed 2-year follow-up measurements. MVPA and sedentary patterns were measured by means of accelerometry, BMD-(total proximal femur and lumbar spine (L1-L4)) by means of dual-energy X-ray absorptiometry (DXA), and physical function-by means of physical tests. In older women, sedentary bouts >60 min were inversely associated with handgrip strength (ß = -2.03, 95% CI: from -3.43 to -0.63). The prospective analyses showed that changes in sedentary bouts (20 to 30 min and >60 min) were inversely associated with changes in the lumbar spine's BMD (ß = -0.01, 95% CI: from -0.01 to -0.00 and ß = -0.03, 95% CI: from -0.06 to -0.01) and the lumbar spine's T-score (ß = -0.06, 95% CI: from -0.10 to -0.01 and ß = -0.27, 95% CI: from -0.49 to -0.04), respectively. In older women, sedentary patterns are cross-sectionally associated with handgrip strength and prospectively associated with BMD independent of MVPA.

Physical activity is associated with functional capacity of older women with osteosarcopenic obesity: 24-month prospective study.

BACKGROUND/OBJECTIVES: Physical activity (PA) could be effective in the prevention of functional disability in older women, especially for those with body composition abnormalities. The aim this study was to analyze the association of total PA and in different domains with physical function and functional capacity in older women with or without osteosarcopenic obesity (OSO), as well as to assess the risk of functional disability in osteosarcopenic obesity older women insufficiently active. SUBJECTS/METHODS: The study included 152 Brazilian older women, aged 60 years and older. Body composition was measured by dual energy X-ray absorptiometry (DXA) and physical function by physical tests. Functional capacity and PA were self-reported. RESULTS: In older women without OSO, the practice of leisure-time exercise (ß:-0.23; 95%CI -0.40 to -0.06) and total PA (ß:-0.40; 95%CI -0.57 to -0.23) is inversely associated with dependence in ADL. In older women with OSO, the practice of leisure-time exercise was inversely associated with physical function (ß:0.88; 95%CI 0.31-1.46) and functional capacity (ß:-1.05; 95%CI 1.64 to -0.45), while total PA (ß:-1.03; 95%CI -1.93 to -0.13) was inversely associated with functional capacity, independent of control variables. In addition, older women with OSO who remained insufficiently active in leisure-time exercise (HR:2.28; 95%CI 1.04-4.99) and locomotion (HR:2.62; 95%CI 1.28-5.36) domains presented risk for functional disability. CONCLUSIONS: PA is inversely associated with physical function and functional capacity in older women with or without OSO, and older women with OSO who are insufficiently active in leisure-time exercise and locomotion domains presented a higher risk for functional disability.

Practice of physical activity and dysmobility syndrome in community-dwelling older adults.

The aim this study was to analyze the association between insufficient physical activity and dysmobility syndrome (DS) in community-dwelling older adults. In total, 375 subjects were evaluated aged ≥60 years. For the diagnosis of DS the presence of ≥3 clinical factors was considered: (a) low muscle mass; (b) low muscular strength; (c) low gait speed; (d) high body fat, and (e) osteoporosis. Information relating to the practice of habitual physical activity (HPA) was obtained using a questionnaire and accelerometry. The chi-square test was used to verify the association between HPA and DS and analysis of binary logistic regression to build multiple models. Insufficiently active older adults are approximately 2 times (95% confidence interval, 1.14-3.79) more likely to have DS, independent of body mass index, smoking and ethnicity. The insufficient practice of physical activity is associated with DS in older adults, mainly in women and older.

Relationship between obesity, sarcopenia, sarcopenic obesity, and bone mineral density in elderly subjects aged 80 years and over.

OBJECTIVE: This study sought to analyze the relationship between the components and aggravations of body composition (obesity, sarcopenia, and sarcopenic obesity) and bone mineral density in elderly subjects aged ≥80 years. METHODS: A cross-sectional study design was utilized to assess 128 subjects aged between 80 and 95 years. Body composition and bone mineral density were measured by dual energy X-ray absorptiometry. Gait speed was assessment by walking test. The statistical analyses included Spearman's correlation, one-way analysis of variance, the chi-squared test, and binary logistic regression analysis. RESULTS: The elderly subjects with sarcopenia had lower bone mineral density compared to the obesity group, with higher risk for presence of osteopenia/osteoporosis in the spine (OR: 2.81; CI: 1.11-7.11) and femur (OR: 2.75; CI: 1.02-7.44). Obesity was shown to be a protective factor for osteopenia/osteoporosis in the spine (OR: 0.43; CI: 0.20-0.93) and femur (OR: 0.27; CI: 0.12-0.62). CONCLUSION: It was found that lean mass is more directly related to bone mineral density (total, femur, and spine) and sarcopenia is associated with osteopenia/osteoporosis. Obesity represents a possible protective factor for osteopenia/osteoporosis in elderly subjects aged 80 years and over.

OBJETIVO: O objetivo do presente estudo foi analisar a relação entre os componentes e agravos da composição corporal (obesidade, sarcopenia e obesidade sarcopênica) com a densidade mineral óssea em idosos com idade ≥ 80 anos. MÉTODOS: Estudo com delineamento transversal que avaliou 128 sujeitos com idade entre 80 e 95 anos. A composição corporal e densidade mineral óssea foram mensuradas por meio da técnica de absorciometria de raios X de dupla energia. A velocidade de caminhada foi avaliada pelo teste de caminhada usual. Para análise estatística foram realizados os testes de correlação de Spearman, análise de variância com um fator, teste qui-quadrado e análise de regressão logística binária. RESULTADOS: Os idosos com sarcopenia apresentaram valores menores de DMO quando comparados com o grupo obesidade com maior chance de risco para a presença de osteopenia/osteoporose na coluna (OR: 2,81; IC: 1,11-7,11) e fêmur (OR: 2,75 IC: 1,02-7,44). Obesidade apresentou fator de proteção para osteopenia/osteoporose na coluna (OR: 0,43; IC: 0,20-0,93) e fêmur (OR: 0,27; IC: 0,12-0,62). CONCLUSÃO: Observou-se que a massa magra está diretamente relacionada com a DMO (total, fêmur e coluna) e que a sarcopenia está associada à osteopenia/osteoporose em idosos com 80 anos ou mais.

Relationship between obesity, sarcopenia, sarcopenic obesity, and bone mineral density in elderly subjects aged 80 years and over / Relação entre obesidade, sarcopenia, obesidade sarcopênica e densidade mineral óssea em idosos com 80 anos ou mais

ABSTRACT Objective This study sought to analyze the relationship between the components and aggravations of body composition (obesity, sarcopenia, and sarcopenic obesity) and bone mineral density in elderly subjects aged ≥80 years. Methods A cross-sectional study design was utilized to assess 128 subjects aged between 80 and 95 years. Body composition and bone mineral density were measured by dual energy X-ray absorptiometry. Gait speed was assessment by walking test. The statistical analyses included Spearman's correlation, one-way analysis of variance, the chi-squared test, and binary logistic regression analysis. Results The elderly subjects with sarcopenia had lower bone mineral density compared to the obesity group, with higher risk for presence of osteopenia/osteoporosis in the spine (OR: 2.81; CI: 1.11-7.11) and femur (OR: 2.75; CI: 1.02-7.44). Obesity was shown to be a protective factor for osteopenia/osteoporosis in the spine (OR: 0.43; CI: 0.20-0.93) and femur (OR: 0.27; CI: 0.12-0.62). Conclusion It was found that lean mass is more directly related to bone mineral density (total, femur, and spine) and sarcopenia is associated with osteopenia/osteoporosis. Obesity represents a possible protective factor for osteopenia/osteoporosis in elderly subjects aged 80 years and over.

RESUMO Objetivo Analisar a relação entre os componentes e agravos da composição corporal (obesidade, sarcopenia e obesidade sarcopênica) com a densidade mineral óssea em idosos com idade ≥ 80 anos. Métodos Estudo com delineamento transversal que avaliou 128 sujeitos entre 80 e 95 anos. A composição corporal e densidade mineral óssea foram mensuradas por meio da técnica de absorciometria de raios X de dupla energia. A velocidade de caminhada foi avaliada pelo teste de caminhada usual. Para análise estatística foram feitos os testes de correlação de Spearman, análise de variância com um fator, teste qui-quadrado e análise de regressão logística binária. Resultados Os idosos com sarcopenia apresentaram valores menores de DMO quando comparados com o grupo obesidade com maior chance de risco para a presença de osteopenia/osteoporose na coluna (OR: 2,81; IC: 1,11-7,11) e fêmur (OR: 2,75 IC: 1,02-7,44). Obesidade apresentou fator de proteção para osteopenia/osteoporose na coluna (OR: 0,43; IC: 0,20-0,93) e fêmur (OR: 0,27; IC: 0,12-0,62). Conclusão Observou-se que a massa magra está diretamente relacionada com a DMO (total, fêmur e coluna) e que a sarcopenia está associada à osteopenia/osteoporose em idosos com 80 anos ou mais.

Elastic resistance training improved glycemic homeostasis, strength, and functionality in sarcopenic older adults: a pilot study.

The purpose of this study was to verify the effects of 12 weeks of elastic resistance training on the glucose homeostasis, strength and functionally in sarcopenic older adults. Seven sarcopenic subjects (age, 70.71± 8.0 years; body mass index, 22.75±3.1 kg/m2) participated of training protocol with 12 weeks of elastic resistance training. The oral glucose tolerance test, handgrip strength, sit-to-stand test, 4-m walk test, and coordination test were measured at baseline and after training. According to the results, baseline values of area under the curve of glucose and homeostatic model assessment-insulin resistance were significantly lower than after 12 weeks, respectively (808.2±185.0 mmol/L vs. 706.6±114.8 mmol/L, P=0.049; 1.44±0.48 vs. 0.73±0.32, P=0.040). There were a significant improve of HGS (24.3±5.7 kg vs. 27.3±7.3 kg, P=0.01), 4-m walking test (3.64±0.4 sec vs. 3.23±0.3 sec, P=0.04), and STS (10.2±2.3 sec vs. 9.0±1.9 sec, P=0.04) compared with baseline. In conclusion, these findings suggest that elastic resistance training improved glucose homeostasis, strength, and functionality in sarcopenic older adults.

Obesity, sarcopenia, sarcopenic obesity and reduced mobility in Brazilian older people aged 80 years and over.

OBJECTIVE: To analyze which abnormalities in body composition (obesity, sarcopenia or sarcopenic obesity) are related to reduced mobility in older people aged 80 years and older. METHODS: The sample included 116 subjects aged 80 years and older. The body composition was measured using dual-energy X-ray absorptiometry (DXA) and mobility was assessed by motor tests. The χ2 test was used to analyze the proportion of older people with sarcopenia, obesity and sarcopenic obesity based on sex as well as to indicate an association between obesity, sarcopenia, sarcopenic obesity and mobility. Binary logistic regression, adjusted for the variables (sex and osteoarticular diseases), was used to express the magnitude of these associations. One-way analysis of variance was used to compare the mobility of four groups (Normal, Obesity, Sarcopenia and Sarcopenic Obesity). RESULTS: The Sarcopenia Group had lower performance in the lower limbs strength test and in sum of two tests compared with Obesity and Normal Groups. Older people with sarcopenia had higher chance of reduced mobility (OR: 3.44; 95%CI: 1.12-10.52). CONCLUSION: Older people aged 80 years and older with sarcopenia have more chance for reduction in mobility.

Obesity, sarcopenia, sarcopenic obesity and reduced mobility in Brazilian older people aged 80 years and over / Obesidade, sarcopenia, obesidade sarcopênica e mobilidade reduzida em idosos brasileiros com 80 anos ou mais

ABSTRACT Objective: To analyze which abnormalities in body composition (obesity, sarcopenia or sarcopenic obesity) are related to reduced mobility in older people aged 80 years and older. Methods: The sample included 116 subjects aged 80 years and older. The body composition was measured using dual-energy X-ray absorptiometry (DXA) and mobility was assessed by motor tests. The χ2 test was used to analyze the proportion of older people with sarcopenia, obesity and sarcopenic obesity based on sex as well as to indicate an association between obesity, sarcopenia, sarcopenic obesity and mobility. Binary logistic regression, adjusted for the variables (sex and osteoarticular diseases), was used to express the magnitude of these associations. One-way analysis of variance was used to compare the mobility of four groups (Normal, Obesity, Sarcopenia and Sarcopenic Obesity). Results: The Sarcopenia Group had lower performance in the lower limbs strength test and in sum of two tests compared with Obesity and Normal Groups. Older people with sarcopenia had higher chance of reduced mobility (OR: 3.44; 95%CI: 1.12-10.52). Conclusion: Older people aged 80 years and older with sarcopenia have more chance for reduction in mobility.

RESUMO Objetivo: Analisar quais agravos na composição corporal (obesidade, sarcopenia ou obesidade sarcopênica) estão relacionados à redução da mobilidade em idosos com 80 anos ou mais. Métodos: A amostra foi constituída por 116 sujeitos com idade igual ou superior a 80 anos. A composição corporal foi mensurada pela técnica de absorciometria de raios X de dupla energia (DXA), e a mobilidade foi avaliada por testes motores. O teste χ2foi utilizado para analisar a proporção de idosos com sarcopenia, obesidade e obesidade sarcopênica, de acordo com o sexo, bem como para indicar a associação entre obesidade, sarcopenia, obesidade sarcopênica e mobilidade. A análise de regressão logística binária, ajustada pelas variáveis (sexo e doenças osteoarticulares), foi utilizada para expressar a magnitude das associações. A análise de variância foi usada para comparar a mobilidade entre os quatro grupos (Normal, Obesidade, Sarcopenia e Obesidade Sarcopênica). Resultados: O Grupo Sarcopenia apresentou menor desempenho no teste de força de membros inferiores e na soma dos dois testes, comparado aos Grupos Obesidade e Normal. Idosos com sarcopenia apresentaram maior chance de redução da mobilidade (OR: 3,44; IC95%: 1,12-10,52). Conclusão: Idosos com idade igual ou superior a 80 anos com sarcopenia têm mais chance de redução da mobilidade.

Association of insufficient physical activity with sarcopenia and sarcopenic obesity in individuals aged 50 years or more / Análise da associação da prática insuficiente de atividade física com sarcopenia e obesidade sarcopênica em indivíduos com idade igual ou superior a 50 anos

ABSTRACT Objective: To analyze the association of insufficient physical activity in different domains with sarcopenia or sarcopenic obesity in patients aged ³50 years. Methods: The sample consisted of 770 males and females. Sarcopenia was diagnosed when the individual had: (1) low muscle mass and muscle strength; or (2) low walking speed and low muscle mass; sarcopenic obesity was diagnosed when individuals were at risk of obesity and sarcopenia. Muscle mass was given by a predictive equation, and then the muscle mass index (in kg/m²) was given by muscle mass divided by height squared. Muscle strength, in kg, was given by measuring handgrip strength with a digital dynamometer. The 4m walk test evaluated walking sped. Low muscle mass, muscle strength, and walking speed were defined as the respective values below the 25th percentile, and risk of obesity was defined as body mass index ³25kg/m2. Results: Habitual physical activity was investigated by a questionnaire. Insufficient leisure-time physical activity was associated with sarcopenia (OR=2.55; 95%CI=1.10-5.88). In addition, insufficient leisure-time physical activity (OR=4.75; 95%CI=1.64-13.72), leisure-time and commuting physical activities (OR=2.49; 95%CI=1.02-6.11, and habitual physical activity (OR=3.55; 95%CI=1.0-11.79) were associated with sarcopenic obesity. Conclusion: Insufficient physical activity is associated with sarcopenia or sarcopenic obesity in the study individuals aged ³50years.

RESUMO Objetivo: Analisar a associação entre a prática insuficiente de atividade física em diferentes domínios e a presença de sarcopenia ou obesidade sarcopênica em indivíduos com idade maior ou igual a 50 anos. Métodos: A amostra foi constituída por 770 indivíduos de ambos os sexos. Para o diagnóstico da sarcopenia, considerou--se: (1) baixas massa e força muscular; ou (2) baixa velocidade de locomoção e baixa massa muscular; para o diagnóstico de obesidade sarcopênica, foram considerados aqueles com indicativo de risco para obesidade e sarcopenia. A massa muscular foi mensurada por meio de equação preditiva e, posteriormente, foi calculado o índice de massa muscular em kg/m² a partir da razão entre massa muscular e estatura. A força muscular foi estimada, em kg, por força de preensão manual através de um dinamômetro digital. O teste de caminhada de quatro metros foi utilizado para avaliar a velocidade de locomoção. Foram considerados com baixas massa muscular, força muscular e velocidade de locomoção os indivíduos com valores abaixo do percentil 25; já os indivíduos com indicativo de risco para obesidade foram aqueles com valores de índice de massa corporal igual ou superior a 25kg/m2. A prática de atividade física habitual foi avaliada por questionário autorreferido. Resultados: A prática insuficiente de exercício físico no lazer associou-se à sarcopenic (OR=2,55; IC95%=1,10-5,88). Além disso, a prática insuficiente de exercício físico no lazer (OR=4,75; IC95%=1,64-13,72) e atividade física no lazer e locomoção (OR=2,49; IC95%=1,02-6,11), bem como a atividade física habitual (OR=3,55; IC95%=1,07-11,79) se associaram à obesidade sarcopênica. Conclusão: A prática insuficiente de atividade física associou-se à sarcopenia ou à obesidade sarcopênica em indivíduos com idade maior ou igual a 50 anos na amostra investigada.

Factors associated with mobility of the oldest old / Fatores associados à mobilidade de idosos longevos

Abstract Introduction: Several factors can be associated to the reduction of mobility among the elderly. Early identification of these factors is crucial, since it may lead to prevention of functional dependencies. Objective: To analyze the association between mobility, sociodemographic factors and the prevalence of noncommunicable chronic diseases (NCDs) in oldest old. Methods: The sample consisted of 120 elderly persons aged (80 and 95 years), with 76 of them being women (83 ± 3 years) and 44 of them men (83 ± 3 years). Sociodemographic factors and NCDs which we studied were: age, gender, marital status, education, nutritional status, ethnicity, hypertension, diabetes and osteoarticular diseases. Mobility was analyzed using a battery of Physical Performance Tests. For statistical analysis we used the chi-square test and binary logistic regression to examine the relationship between sociodemographic factors, NCDs and mobility. SPSS (17.0) software was used for this and the significance level was set at 5%. Results: Level of education (p ≤ 0.001) and age (p = 0.034) are the two factors related to low mobility. However, the model built by multiple logistic regression analysis revealed that age is independently related to limited mobility in oldest old people (OR 3.29; 95% CI 1.09 to 9.87). Conclusion: Thus, oldest old >85 years are at a greater risk of decreased mobility independent of their education, marital and nutritional statuses and gender. We encourage further studies in this area. Studies which will not only address those facts considered in this study but that also examine family-related aspects, especially using longitudinal studies.

Resumo Introdução: A redução da mobilidade pode estar relacionada a vários fatores e a identificação precoce desses fatores torna-se fundamental, uma vez que pode auxiliar na prevenção da dependência funcional de idosos. Objetivo: analisar a relação entre mobilidade, fatores sociodemográficos e prevalência de doenças crônicas não transmissíveis (DCNT) em idosos longevos. Métodos: A amostra foi constituída por 120 idosos com idade entre 80 e 95 anos (83 ± 3 anos), sendo 76 mulheres (83 ± 3 anos) e 44 homens (83 ± 3 anos). Os fatores sociodemográficos e DCNT investigados foram: idade, sexo, estado civil, escolaridade, etnia, estado nutricional, hipertensão, diabetes e doenças osteoarticulares. A mobilidade foi analisada por meio da bateria Physical Perfomance Tests. Para tratamento estatístico foram empregados os testes qui-quadrado e regressão logística binária para analisar a associação entre fatores sociodemográficos, DCNT e a mobilidade. O software utilizado foi o SPSS (17.0) e o nível de significância estabelecido foi de 5%. Resultados: Os fatores relacionados à baixa mobilidade foram a escolaridade (p ≤ 0,001) e idade (p = 0,034). Contudo, o modelo múltiplo construído pela análise de regressão logística revelou que a idade está independentemente relacionada à limitação da mobilidade em idosos longevos (OR 3,29; IC95% 1,09-9,87). Conclusão: Dessa forma, idosos longevos com idade >85 anos apresentam mais chance de risco para limitação da mobilidade independente da escolaridade, dos estados civil e nutricional, e do sexo. Incentiva-se a futuros estudos além de abordar os aspectos trabalhados no presente estudo, averiguar também aspectos familiares, e principalmente, em estudos longitudinais.